Cold atmospheric plasma jet array for transdermal drug delivery

Abstract Transdermal drug delivery (TDD) is an important drug delivery method, and cold atmospheric plasma has been proven its potential as a TDD approach. In this study, a 9‐channel plasma jet array was designed to enhance TDD efficiency. The Franz diffusion experiment showed that the TDD efficiency of the drug across the skin was enhanced about 2–110 times after the plasma jet array treatment. The histological analysis showed that the structure of the stratum corneum could be destroyed by the plasma. Further investigations indicated that the reactive oxygen species of the plasma jet play a key role in enhancing TDD efficiency. Our results indicated that the plasma jet array is a potential and effective TDD approach.