[The relationship between resting heart rate and all-cause mortality among the Chinese oldest-old aged more than 80: a prospective cohort study].

Objective: To explore the association between resting heart rate(RHR) and all-cause mortality among the Chinese oldest-old aged more than 80. Methods: Using a total of seven surveys or follow-ups data (1998, 2000, 2002, 2005, 2008, 2011 and 2014) from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). A total of 17 886 elderly over 80 years old were selected as subjects, their resting heart rate were measured though baseline survey and the survival outcome and death time of the subjects were followed up. The subjects were divided into 6 groups according to their resting heart rate. Cox regression model was used to estimate the effect of resting heart rate on mortality risk. The interaction of age, gender and resting heart rate was also analyzed by likelihood ratio test. Results: The age of subjects M (P25, P75) was 92 (86, 100) years old, including 10 531 females (58.9%) and there were 13 598 participants died, the mortality rate was 195.5 per 1 000 person-years. Multivariate Cox regression analysis showed that compared to the control group (60-69 pbm/min), the hazard ratio of the elderly are 1.06 (95%CI: 1.02, 1.11), 1.09 (95%CI: 1.04, 1.15), 1.23 (95%CI: 1.14, 1.34), 1.25 (95%CI: 1.08, 1.44) in the group of RHR between 70-79, 80-89, 90-99 and ≥100 pbm/min and P values are all less than 0.05. Likelihood ratio test showed that RHR and age had an interaction effect. (P for interaction=0.011). Conclusion: The risk of all-cause death increased with the increase of resting heart rate and this relationship was stronger between the 80-89 years old people.目的： 探讨中国80岁及以上高龄老人静息心率与全因死亡风险的关联。 方法： 采用中国老年健康影响因素跟踪调查（CLHLS）七次（1998、2000、2002、2005、2008、2011和2014年）调查数据。以年龄在80周岁以上的17 886名高龄老人为研究对象，通过基线调查收集对象的静息心率次数，并随访研究对象的生存结局和死亡时间。根据研究对象的静息心率次数将其分为6组。采用Cox比例风险模型评估静息心率与死亡风险间的关联，并采用似然比检验分析年龄、性别与静息心率的交互作用。 结果： 17 886名研究对象的年龄M（P25，P75）为92（86，100）岁，其中女性10 531名（58.9%），共计13 598名老年人死亡，死亡密度为195.5/1 000人年。多因素Cox比例风险回归模型分析结果显示，与静息心率60~69次/min组相比，静息心率70~79、80~89、90~99、≥100次/min的死亡风险HR（95%CI）值分别为1.06（1.02，1.11），1.09（1.04，1.15），1.23（1.14，1.34），1.25（1.08，1.44）（P值均<0.05）。似然比检验发现，静息心率与年龄存在交互作用（P交互值=0.011）。 结论： 高龄老人全因死亡的发生风险随静息心率次数的增加而上升，在80~89岁老年人群中相对显著。.