儿茶酚
生物分子
材料科学
胺气处理
嫁接
催化作用
表面改性
化学工程
纳米技术
组合化学
化学
有机化学
聚合物
工程类
复合材料
作者
Peng Gao,Hua Qiu,Kaiqin Xiong,Xiangyang Li,Qiufen Tu,Huaiyu Wang,Nan Lyu,Chen Xiao,Nan Huang,Zhilu Yang
出处
期刊:Biomaterials
[Elsevier]
日期:2020-03-19
卷期号:248: 119981-119981
被引量:44
标识
DOI:10.1016/j.biomaterials.2020.119981
摘要
Regarding the high requirement of cardiac and vascular implants in tissue engineering, a novel concept of surface chemistry strategy featuring multiple functions is proposed in this study, which provides glutathione peroxidase (GPx)-like catalytic activity and allows secondary reactions for grafting functional biomolecules. The suggested strategy is the fabrication of a metal-catechol-(amine) network (MCAN) containing copper ions with GPx-like activity, amine-bearing hexamethylenediamine (HD) and wet adhesive catechol dopamine (DA). With a simple one-step molecular/ion co-assembly, the developed copper-DA-HD (CuII-DA/HD) network can be used to catalyze the generation of therapeutic nitric oxide (NO) gas in a durable and dose-controllable manner. The primary amine groups in the CuII-DA/HD network facilitate the secondary immobilization of bivalirudin (BVLD) to further provide an antithrombotic activity as supplement to the functions of NO. The CuII-DA/HD + BVLD coating functionalized on cardiovascular stents successfully improved thromboresistance, anti-restenosis, and promotes re-endothelialization in vivo. With regard to the ease of operation and low cost, the synergetic modification using MCAN strategy is of great potential for developing multifunctional blood-contacting materials/devices.
科研通智能强力驱动
Strongly Powered by AbleSci AI