荧光团
荧光
双功能
双膦酸盐
结合
红外线的
化学
基质骨
材料科学
纳米技术
生物物理学
骨质疏松症
光学
解剖
病理
生物化学
软骨
医学
数学分析
物理
数学
催化作用
生物
作者
Hoon Hyun,Hirofumi Wada,Kai Bao,Julien Gravier,Yogesh Yadav,Matt Laramie,Maged Henary,John V. Frangioni,Hak Choi
标识
DOI:10.1002/anie.201404930
摘要
The conventional method for creating targeted contrast agents is to conjugate separate targeting and fluorophore domains. A new strategy is based on the incorporation of targeting moieties into the non-delocalized structure of pentamethine and heptamethine indocyanines. Using the known affinity of phosphonates for bone minerals in a model system, two families of bifunctional molecules that target bone without requiring a traditional bisphosphonate are synthesized. With peak fluorescence emissions at approximately 700 or 800 nm, these molecules can be used for fluorescence-assisted resection and exploration (FLARE) dual-channel imaging. Longitudinal FLARE studies in mice demonstrate that phosphonated near-infrared fluorophores remain stable in bone for over five weeks, and histological analysis confirms their incorporation into the bone matrix. Taken together, a new strategy for creating ultra-compact, targeted near-infrared fluorophores for various bioimaging applications is described.
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