肺癌
癌变
疾病
背景(考古学)
纤维化
肺
间充质干细胞
生物
肺纤维化
生物信息学
癌症
医学
病理
遗传学
内科学
古生物学
作者
Jeffrey C. Horowitz,John J. Osterholzer,Antonia Marazioti,Georgios T. Stathopoulos
出处
期刊:The European respiratory journal
[European Respiratory Society]
日期:2016-03-30
卷期号:47 (6): 1842-1854
被引量:24
标识
DOI:10.1183/13993003.01201-2015
摘要
Lung cancer and pulmonary fibrosis are common, yet distinct, pathological processes that represent urgent unmet medical needs. Striking clinical and mechanistic parallels exist between these distinct disease entities. The goal of this article is to examine lung fibrosis from the perspective of cancer-associated phenotypic hallmarks, to discuss areas of mechanistic overlap and distinction, and to highlight profibrotic mechanisms that contribute to carcinogenesis. Ultimately, we speculate that such comparisons might identify opportunities to leverage our current understanding of the pathobiology of each disease process in order to advance novel therapeutic approaches for both. We anticipate that such “outside the box” concepts could be translated to a more precise and individualised approach to fibrotic diseases of the lung.
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