Study on preparation and main drug content determination of baicalin liposomes

Objective:To prepare and establish a method for the determination of baicalin liposomes.Methods:Baicalin liposome was prepared by reverse evaporating method,the content of baicalin in baicalin lipsomes was determined by HPLC.Results:The mean diameter and entrapment efficiency of baicalin lipsomes were 350nm and 60.1%.The linear range of baicalin was 0.29～1.45μg(r=0.9997) and the average recovery rate was 100.1%,RSD=0.2%(n=6).Conclusion:The preparation of baicalin lipsomes is simple and the content determination is simple,reliable and reproducible,which can be used in the quality control of baicalin lipsomes.