化学
立体中心
转移加氢
芳基
催化作用
铱
分子内力
对映选择合成
酮
组合化学
不对称氢化
功能群
乙醇
有机化学
钌
烷基
聚合物
作者
Xixia Tang,Qian Lu,Guixia Liu,Zheng Huang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-06-26
卷期号:25 (26): 4950-4954
被引量:1
标识
DOI:10.1021/acs.orglett.3c01880
摘要
Asymmetric transfer hydrogenation of 1-aryl-1-alkylethenes with ethanol was developed with a chiral (PCN)Ir complex as the precatalyst, featuring high enantioselectivities, good functional group tolerance, and operational simplicity. The method is further applied to formal intramolecular asymmetric transfer hydrogenation of alkenols without an external H-donor, producing a tertiary stereocenter and remote ketone group simultaneously. The utility of the catalytic system was highlighted by gram scale synthesis and the synthesis of the key precursor of (R)-xanthorrhizol.
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