Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (TRACK-TBI) Study

医学 创伤性脑损伤 格拉斯哥昏迷指数 蛛网膜下腔出血 头部受伤 磁共振成像 急诊科 神秘的 放射科 麻醉 外科 病理 精神科 替代医学
作者
John K. Yue,Esther L. Yuh,Mahmoud Elguindy,Xiaoying Sun,Thomas A. van Essen,Hansen Deng,Patrick Belton,Gabriela Satris,Justin C. Wong,Alex B. Valadka,Frederick K. Korley,Claudia S. Robertson,Michael McCrea,Murray B. Stein,Ramon Diaz‐Arrastia,Kevin Wang,Nancy Temkin,Anthony M. DiGiorgio,Phiroz E. Tarapore,Michael C. Huang,Amy J. Markowitz,Ava M. Puccio,Pratik Mukherjee,David O. Okonkwo,Sonia Jain,Geoffrey T. Manley
出处
期刊:Journal of Neurotrauma [Mary Ann Liebert, Inc.]
卷期号:41 (11-12): 1310-1322
标识
DOI:10.1089/neu.2023.0253
摘要

Isolated traumatic subarachnoid hemorrhage (tSAH) after traumatic brain injury (TBI) on head computed tomography (CT) scan is often regarded as a "mild" injury, with reduced need for additional workup. However, tSAH is also a predictor of incomplete recovery and unfavorable outcome. This study aimed to evaluate the characteristics of CT-occult intracranial injuries on brain magnetic resonance imaging (MRI) scan in TBI patients with emergency department (ED) arrival Glasgow Coma Scale (GCS) score 13-15 and isolated tSAH on CT. The prospective, 18-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (TRACK-TBI; enrollment years 2014-2019) enrolled participants who presented to the ED and received a clinically-indicated head CT within 24 h of TBI. A subset of TRACK-TBI participants underwent venipuncture within 24 h for plasma glial fibrillary acidic protein (GFAP) analysis, and research MRI at 2-weeks post-injury. In the current study, TRACK-TBI participants age ≥17 years with ED arrival GCS 13-15, isolated tSAH on initial head CT, plasma GFAP level, and 2-week MRI data were analyzed. In 57 participants, median age was 46.0 years [quartile 1 to 3 (Q1-Q3): 34-57] and 52.6% were male. At ED disposition, 12.3% were discharged home, 61.4% were admitted to hospital ward, and 26.3% to intensive care unit. MRI identified CT-occult traumatic intracranial lesions in 45.6% (26 of 57 participants; one additional lesion type: 31.6%; 2 additional lesion types: 14.0%); of these 26 participants with CT-occult intracranial lesions, 65.4% had axonal injury, 42.3% had subdural hematoma, and 23.1% had intracerebral contusion. GFAP levels were higher in participants with CT-occult MRI lesions compared with without (median: 630.6 pg/mL, Q1-Q3: [172.4-941.2] vs. 226.4 [105.8-436.1],
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