GPX4
髓系白血病
下调和上调
癌症研究
生物
白血病
细胞生物学
小RNA
免疫学
遗传学
谷胱甘肽过氧化物酶
基因
内分泌学
超氧化物歧化酶
氧化应激
作者
Zhixin Ma,Wenle Ye,Xin Huang,Xia Li,Fenglin Li,Xiangjie Lin,Chao Hu,Jinghan Wang,Jie Jin,Bo Zhu,Jiansong Huang
出处
期刊:Aging
[Impact Journals, LLC]
日期:2023-11-29
卷期号:15 (22): 13486-13503
被引量:1
标识
DOI:10.18632/aging.205257
摘要
Ferroptosis induction through the suppression of glutathione peroxidase 4 (GPX4) and apoptosis-inducing factor mitochondria-associated 2 (AIFM2) has proven to be an effective approach in eliminating chemotherapyresistant cells of various types.However, a comprehensive understanding of the roles of GPX4 and AIFM2 in acute myeloid leukemia (AML) has not yet been achieved.Using cBioPortal, DepMap, GEPIA, Metascape, and ONCOMINE, we compared the transcriptional expression, survival data, gene mutation, methylation, and network analyses of GPX4-and AIFM2-associated signaling pathways in AML.The results revealed that high expression levels of GPX4 and AIFM2 are associated with an adverse prognosis for AML patients.Overexpression of AIFM2 correlated with elevated mutation frequencies in NPM1 and DNMT3A.GPX4 upregulation modulated the following pathways: GO:0045333, cellular respiration; R-HSA-5389840, mitochondrial translation elongation; GO:0009060, aerobic respiration; R-HSA-9609507, protein localization; and R-HSA-8953854, metabolism of RNA.On the other hand, the overexpression of AIFM2 influenced the following processes: GO:0048704, embryonic skeletal system morphogenesis; GO:0021546, rhombomere development; GO:0009954, proximal/distal pattern formation; and GO:0048732, gland development.This study identifies the high expression of GPX4 and AIFM2 as novel biomarkers predicting a poor prognosis for AML patients.Furthermore, ferroptosis induction may improve the stratified treatment of AML.
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