肿瘤微环境
免疫系统
巨噬细胞极化
微泡
血管生成
癌症研究
细胞生物学
转移
肿瘤进展
表型
生物
小RNA
免疫学
癌症
基因
遗传学
作者
Kangning Li,Tao Xie,Yong Li,Xuan Huang
出处
期刊:Carcinogenesis
[Oxford University Press]
日期:2024-03-06
卷期号:45 (6): 363-377
被引量:1
标识
DOI:10.1093/carcin/bgae021
摘要
Abstract Long non-coding RNAs (lncRNAs) have been established as pivotal players in various cellular processes, encompassing the regulation of transcription, translation and post-translational modulation of proteins, thereby influencing cellular functions. Notably, lncRNAs exert a regulatory influence on diverse biological processes, particularly in the context of tumor development. Tumor-associated macrophages (TAMs) exhibit the M2 phenotype, exerting significant impact on crucial processes such as tumor initiation, angiogenesis, metastasis and immune evasion. Elevated infiltration of TAMs into the tumor microenvironment (TME) is closely associated with a poor prognosis in various cancers. LncRNAs within TAMs play a direct role in regulating cellular processes. Functioning as integral components of tumor-derived exosomes, lncRNAs prompt the M2-like polarization of macrophages. Concurrently, reports indicate that lncRNAs in tumor cells contribute to the expression and release of molecules that modulate TAMs within the TME. These actions of lncRNAs induce the recruitment, infiltration and M2 polarization of TAMs, thereby providing critical support for tumor development. In this review, we survey recent studies elucidating the impact of lncRNAs on macrophage recruitment, polarization and function across different types of cancers.
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