Synthesis, DNA Binding Studies, and Molecular Docking of Tetrahydroquinoline-3-Carbonitrile Derivatives

In this study, a series of 2-amino-4-(substituted phenyl)-5,6,7,8-tetrahydroquinoline -3-carbonitrile derivatives (IVa-j) was synthesized using a one-pot process. The titled compounds were successfully synthesized by employing aromatic aldehydes with satisfactory yields. Docking studies were directed to explore the DNA-binding interactions of the synthesized compounds. These studies involved docking the compounds with B-DNA (PDB ID: 1BNA) to investigate the preferred binding sites, interaction modes, and binding affinities.