牛磺胆酸
脂肪组织
胆酸
褐色脂肪组织
肠道菌群
内分泌学
内科学
胆汁酸
G蛋白偶联胆汁酸受体
化学
粪便
生物
生物化学
微生物学
医学
作者
Yize Liu,Zheng-Yun Jin,Junxia Wang,Danqi Wang,Hongye Liu,Dongxu Li,Jun Zhu,Zhao‐Bo Luo,Sheng‐Zhong Han,Shuangyan Chang,Liuhui Yang,Jin‐Dan Kang,Lin‐Hu Quan
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:14 (10): 4696-4705
被引量:6
摘要
Obesity is a global health problem strongly linked to gut microbes and their metabolites. In this study, ginsenoside Rg1 (Rg1) reduced lipid droplet size and hepatic lipid accumulation by activating uncoupling protein 1 expression in brown adipose tissue (BAT), which in turn inhibited high-fat diet (HFD)-induced weight gain in mice. Furthermore, the intestinal flora of mice was altered, the abundance of Lachnoclostridium, Streptococcus, Lactococcus, Enterococcus and Erysipelatoclostridium was upregulated, and the concentrations of fecal bile acids were altered, with cholic acid and taurocholic acid concentrations being significantly increased. In addition, the beneficial effects of Rg1 were eliminated in mice treated with a combination of antibiotics. In conclusion, these results suggest that Rg1 activates BAT to counteract obesity by regulating gut microbes and bile acid composition in HFD-fed mice.
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