On-skin biosensors for noninvasive monitoring of postoperative free flaps and replanted digits

医学 自由襟翼 外科 皮瓣
作者
Hao Wu,Zhuo Li,Zhao Xu,Xin Huang,Wei Guo,Jun Zhao,Jinwen Zhang,Shaoyu Liu,Miao Tang,Yuqi Qiu,Ganguang Yang,Juntong Zhu,Lili Liu,Yingjie Wu,Lei Wei,Pan Zhou,Zhouping Yin,Zhenbing Chen,Yutian Liu
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science]
卷期号:15 (693) 被引量:21
标识
DOI:10.1126/scitranslmed.abq1634
摘要

Severe soft tissue defects and amputated digits are clinically common injuries. Primary treatments include surgical free flap transfer and digit replantation, but these can fail because of vascular compromise. Postoperative monitoring is therefore crucial for timely detection of vessel obstruction and survival of replanted digits and free flaps. However, current postoperative clinical monitoring methods are labor intensive and highly dependent on the experience of nurses and surgeons. Here, we developed on-skin biosensors for noninvasive and wireless postoperative monitoring based on pulse oximetry. The on-skin biosensor was made of polydimethylsiloxane with gradient cross-linking to create a self-adhesive and mechanically robust substrate that interfaces with skin. The substrate was shown to exhibit appropriate adhesion on one side for both high-fidelity measurements of the sensor and low risk of peeling injury to delicate tissues. The other side demonstrated mechanical integrity to facilitate flexible hybrid integration of the sensor. Validation studies using a model of vascular obstruction in rats demonstrated the effectiveness of the sensor in vivo. Clinical studies indicated that the on-skin biosensor was accurate and more responsive than current clinical monitoring methods in identifying microvascular conditions. Comparisons with existing monitoring techniques, including laser Doppler flowmetry and micro-lightguide spectrophotometry, further verified the sensor’s accuracy and ability to identify both arterial and venous insufficiency. These findings suggest that this on-skin biosensor may improve postoperative outcomes in free flap and replanted digit surgeries by providing sensitive and unbiased data directly from the surgical site that can be remotely monitored.
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