亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

On-skin biosensors for noninvasive monitoring of postoperative free flaps and replanted digits

医学 自由襟翼 外科 皮瓣
作者
Hao Wu,Zhuo Li,Zhao Xu,Xin Huang,Wei Guo,Jun Zhao,Jinwen Zhang,Shaoyu Liu,Miao Tang,Yuqi Qiu,Ganguang Yang,Juntong Zhu,Lili Liu,Yingjie Wu,Lei Wei,Pan Zhou,Zhouping Yin,Zhenbing Chen,Yutian Liu
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science]
卷期号:15 (693) 被引量:21
标识
DOI:10.1126/scitranslmed.abq1634
摘要

Severe soft tissue defects and amputated digits are clinically common injuries. Primary treatments include surgical free flap transfer and digit replantation, but these can fail because of vascular compromise. Postoperative monitoring is therefore crucial for timely detection of vessel obstruction and survival of replanted digits and free flaps. However, current postoperative clinical monitoring methods are labor intensive and highly dependent on the experience of nurses and surgeons. Here, we developed on-skin biosensors for noninvasive and wireless postoperative monitoring based on pulse oximetry. The on-skin biosensor was made of polydimethylsiloxane with gradient cross-linking to create a self-adhesive and mechanically robust substrate that interfaces with skin. The substrate was shown to exhibit appropriate adhesion on one side for both high-fidelity measurements of the sensor and low risk of peeling injury to delicate tissues. The other side demonstrated mechanical integrity to facilitate flexible hybrid integration of the sensor. Validation studies using a model of vascular obstruction in rats demonstrated the effectiveness of the sensor in vivo. Clinical studies indicated that the on-skin biosensor was accurate and more responsive than current clinical monitoring methods in identifying microvascular conditions. Comparisons with existing monitoring techniques, including laser Doppler flowmetry and micro-lightguide spectrophotometry, further verified the sensor’s accuracy and ability to identify both arterial and venous insufficiency. These findings suggest that this on-skin biosensor may improve postoperative outcomes in free flap and replanted digit surgeries by providing sensitive and unbiased data directly from the surgical site that can be remotely monitored.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
传奇完成签到 ,获得积分10
10秒前
jyy关闭了jyy文献求助
38秒前
丘比特应助怕孤单的思雁采纳,获得10
39秒前
53秒前
59秒前
Akitten发布了新的文献求助10
1分钟前
1分钟前
Li完成签到,获得积分10
1分钟前
1分钟前
自然的衫完成签到 ,获得积分10
1分钟前
1分钟前
阿巴阿巴茶完成签到,获得积分10
2分钟前
lhy发布了新的文献求助10
2分钟前
CipherSage应助科研通管家采纳,获得10
2分钟前
资白玉完成签到 ,获得积分0
2分钟前
华仔应助Akitten采纳,获得10
3分钟前
上官若男应助紫色奶萨采纳,获得10
4分钟前
老石完成签到 ,获得积分10
4分钟前
NexusExplorer应助科研通管家采纳,获得10
4分钟前
4分钟前
紫色奶萨发布了新的文献求助10
4分钟前
紫色奶萨完成签到,获得积分10
4分钟前
华仔应助怕孤单的思雁采纳,获得10
4分钟前
4分钟前
4分钟前
4分钟前
Akitten发布了新的文献求助10
4分钟前
SYLH应助怕孤单的思雁采纳,获得10
4分钟前
4分钟前
科研小白完成签到 ,获得积分10
5分钟前
5分钟前
活力半凡发布了新的文献求助10
5分钟前
5分钟前
婼汐完成签到 ,获得积分10
5分钟前
活力半凡完成签到,获得积分10
6分钟前
Cathy完成签到,获得积分10
6分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
怕孤单的思雁完成签到,获得积分10
7分钟前
闫雪发布了新的文献求助10
7分钟前
gszy1975完成签到,获得积分10
7分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990298
求助须知:如何正确求助?哪些是违规求助? 3532146
关于积分的说明 11256481
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805197
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234