Synthesis, characterization and investigation of antibacterial activity for some new functionalized luminol derivatives

ABSTRACT. The present study describes synthesis of some new luminol derivatives, which might play an important role in biological active agents. These new synthesized compounds are functionalized based on luminol (LM) with different carboxylic drugs such as mefenamic acid, ibuprofen, diclofenac sodium, and ampicillin). Synthesis processes was conducted by converting carboxylic group in the investigated drugs into acid chloride group by reacting with SOCl2. Then the synthesized chloride drug derivatives were reacted with luminol in presences of DMSO and TEA to yield the final target molecules. These compounds were characterized using FTIR, NMR and CHNS techniques. Besides that, their physical properties and solubility were also investigated. Biological activity of the derivatives (TH1-TH4) was investigated using a pathogenic bacterium, Staphylococcus aureus (gram +ve), and Escherichia (E. coli) (gram -ve). The obtained results for antibacterial activity showed that TH1-TH4 derivatives have higher antibacterial activity against these types of bacteria in comparison with pure LM compound and the investigated drugs. KEY WORDS: Luminol, Mefenamic acid, Ibuprofen, Diclofenac sodium, Ampicillin Bull. Chem. Soc. Ethiop. 2023, 37(1), 159-169. DOI: https://dx.doi.org/10.4314/bcse.v37i1.13