自噬
微管蛋白
细胞生物学
线粒体
微管
胶质母细胞瘤
粒体自噬
材料科学
纳米纤维
生物
癌症研究
细胞凋亡
生物物理学
纳米技术
生物化学
作者
Yiwen Zhang,Haoyu You,Zhenhao Zhao,Yifan Luo,Chao Li,Peixin Liu,Hongyi Chen,Yu Wang,Zheng Zhou,Tao Sun,Chen Jiang
标识
DOI:10.1002/adfm.202209216
摘要
Abstract Protective autophagy of mitochondria is an important cause of high mortality in glioblastoma (GBM). Because of its serious impact on the treatment effect, it is in urgent need of combined treatment. Based on the regulatory function of the tubulin system on autophagy and inspired by the natural characteristics of neurofilament regulating tubulin polymerization, an in situ self‐assembled “tubulin trap” is designed. Specifically, the system is a transformable block polymer, which can self‐assemble into spherical nanoparticles in water. After targeting GBM cells, they can transform into nanofibers under the intracellular GSH conditions, interfering with autophagy. The research shows that, in mouse GBM xenograft models, the transformable nanofibers with the function of destroying tubulin homeostasis can be combined with ceramide in the treatment of GBM.
科研通智能强力驱动
Strongly Powered by AbleSci AI