Low growth hormone secretion associated with post-acute sequelae SARS-CoV-2 infection (PASC) neurologic symptoms: A case-control pilot study

医学 激素 内科学 萧条(经济学) 生理学 宏观经济学 经济
作者
Traver J. Wright,Richard B. Pyles,Melinda Sheffield‐Moore,Rachel Deer,Kathleen M. Randolph,Kristen A. McGovern,Christopher P. Danesi,Charles R. Gilkison,Weston W. Ward,J. Vargas,Peyton A. Armstrong,Sarah E. Lindsay,Mohammed Zaidan,Justin Seashore,T Wexler,Brent E. Masel,Randall J. Urban
出处
期刊:Molecular and Cellular Endocrinology [Elsevier]
卷期号:579: 112071-112071 被引量:6
标识
DOI:10.1016/j.mce.2023.112071
摘要

To determine if patients that develop lingering neurologic symptoms of fatigue and "brain fog" after initial recovery from coronavirus disease 2019 (COVID-19) have persistent low growth hormone (GH) secretion as seen in other conditions with similar symptom etiology.In this case-control observational pilot study, patients reporting lingering neurologic post-acute sequelae of SARS-CoV-2 (PASC, n = 10) symptoms at least 6 months after initial infection were compared to patients that recovered from COVID-19 without lingering symptoms (non-PASC, n = 13). We compared basic blood chemistry and select metabolites, lipids, hormones, inflammatory markers, and vitamins between groups. PASC and non-PASC subjects were tested for neurocognition and GH secretion, and given questionnaires to assess symptom severity. PASC subjects were also tested for glucose tolerance and adrenal function.PASC subjects reported significantly worse fatigue, sleep quality, depression, quality of life, and gastrointestinal discomfort compared to non-PASC. Although PASC subjects self-reported poor mental resilience, cognitive testing did not reveal significant differences between groups. Neurologic PASC symptoms were not linked to inflammatory markers or adrenal insufficiency, but were associated with reduced growth hormone secretion.Neurologic PASC symptoms are associated with gastrointestinal discomfort and persistent disruption of GH secretion following recovery from acute COVID-19. (www.gov; NCT04860869).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
涛涛子发布了新的文献求助10
刚刚
huang发布了新的文献求助30
刚刚
安详以晴完成签到,获得积分10
刚刚
周亭完成签到,获得积分10
刚刚
TT完成签到,获得积分10
1秒前
najibveto应助123采纳,获得10
2秒前
2秒前
彭于晏应助zls采纳,获得10
2秒前
李爱国应助Mike采纳,获得10
2秒前
上官若男应助ff采纳,获得10
3秒前
wanci应助请叫我小阿欢采纳,获得10
3秒前
3秒前
Marilinta完成签到,获得积分10
4秒前
4秒前
善学以致用应助xianjingli采纳,获得10
4秒前
katchulailai完成签到,获得积分20
5秒前
朱颜完成签到,获得积分10
5秒前
突突突发布了新的文献求助10
5秒前
exosome发布了新的文献求助10
5秒前
Micahaeler完成签到 ,获得积分10
6秒前
6秒前
awei发布了新的文献求助10
7秒前
九龙飞翔发布了新的文献求助10
7秒前
big ben完成签到 ,获得积分10
7秒前
轻松的雪枫完成签到,获得积分10
8秒前
zzx完成签到,获得积分10
8秒前
无异常完成签到,获得积分10
9秒前
9秒前
思源应助黑煤球采纳,获得10
9秒前
10秒前
肖玖辞完成签到,获得积分10
10秒前
汉堡包应助尚好佳采纳,获得10
10秒前
Bing完成签到,获得积分10
11秒前
11秒前
lxl1996发布了新的文献求助10
11秒前
taoze完成签到,获得积分20
11秒前
传奇3应助冷傲海蓝采纳,获得10
11秒前
11秒前
松溪乾完成签到,获得积分10
11秒前
12秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
An Introduction to Geographical and Urban Economics: A Spiky World Book by Charles van Marrewijk, Harry Garretsen, and Steven Brakman 500
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3151396
求助须知:如何正确求助?哪些是违规求助? 2802862
关于积分的说明 7850843
捐赠科研通 2460290
什么是DOI,文献DOI怎么找? 1309701
科研通“疑难数据库(出版商)”最低求助积分说明 628997
版权声明 601760