普拉克索
萧条(经济学)
抗抑郁药
多巴胺能
多巴胺受体D3
心理学
多巴胺
医学
多巴胺激动剂
临床试验
多巴胺能途径
药理学
精神科
神经科学
内科学
帕金森病
疾病
经济
宏观经济学
焦虑
作者
D. Chamith Halahakoon,Michael Browning
出处
期刊:Current topics in behavioral neurosciences
日期:2023-01-01
标识
DOI:10.1007/7854_2023_458
摘要
Dopaminergic mechanisms are a plausible treatment target for patients with clinical depression but are relatively underexplored in conventional antidepressant medications. There is continuing interest in the potential antidepressant effects of the dopamine receptor agonist, pramipexole, with data from both case series and controlled trials indicating that this agent may produce benefit for patients with difficult-to-treat depression. Pramipexole’s therapeutic utility in depression is likely to be expressed through alterations in reward mechanisms which are strongly influenced by dopamine pathways and are known to function abnormally in depressed patients. Our work in healthy participants using brain imaging in conjunction with computational modelling suggests that repeated pramipexole facilitates reward learning by inhibiting value decay. This mechanism needs to be confirmed in larger clinical trials in depressed patients. Such studies will also allow assessment of whether baseline performance in reward learning in depression predicts therapeutic response to pramipexole treatment.
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