齐拉西酮
赛马鲁肽
精神分裂症(面向对象编程)
心理学
心理治疗师
医学
精神科
利培酮
内分泌学
糖尿病
利拉鲁肽
2型糖尿病
作者
Abrahim N Razzak,Abrahim N Razzak,Lianping Sun,Abrahim N Razzak,Abrahim N Razzak
出处
期刊:Cureus
[Cureus, Inc.]
日期:2024-04-29
摘要
Semaglutide (Ozempic), a GLP-1 receptor agonist effective in weight management, and ziprasidone (Geodon), an antipsychotic with a lower risk of metabolic side effects, are well-established in treating type 2 diabetes and schizophrenia, respectively. However, their interactions and effects on psychiatric symptoms are less understood. In this study, we report a case of a 43-year-old male with schizophrenia and diabetes with exacerbated paranoid delusions upon semaglutide administration for weight loss; symptoms peaked at higher doses and subsided after dose reduction. Concurrently, serum ziprasidone levels were significantly elevated at the dose reduction, suggesting a pharmacokinetic interaction likely due to semaglutide-induced slowed gastric emptying affecting ziprasidone's absorption and metabolism. This study illustrates the need for careful monitoring of psychiatric symptoms and drug levels when these medications are used together. Additionally, further research into their interactions to optimize treatment for patients with coexisting metabolic and psychiatric conditions is warranted.
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