Alteration in Brain Functional Connectivity in Patients with Post-Stroke Cognitive Impairment During Memory Task: A fNIRS Study

记忆广度 心理学 前额叶皮质 听力学 认知 手指敲击 冲程(发动机) 执行职能 工作记忆 物理医学与康复 神经科学 医学 机械工程 工程类
作者
Yongmei Fan,Wenna Peng,Jing Li,Chunjiao Zhu,Ying Zou,Ru-mi Wang,Changjie Zhang,Ying Kong
出处
期刊:Social Science Research Network [Social Science Electronic Publishing]
标识
DOI:10.2139/ssrn.4206603
摘要

Background: Post-stroke cognitive impairment (PSCI) refers to various types of cognitive deterioration after stroke, from mild cognitive impairment (MCI) to dementia. The cortical plastic changes in patients with MCI after stroke have not been entirely illustrated. Objective. This study aimed to reveal the physiological mechanism in patients with cognitive impairment after stroke using the functional connectivity (FC) method.Methods: FC was assessed by dynamic Bayesian inference of the oxygenated hemoglobin concentration signals measured through fNIRS. This signal was recorded from bilateral prefrontal cortex (PFC) and motor Abbreviations FCfunctional connectivity; PFC:prefrontal cortex; MS:motor sense; LMS:left motor sense; RMS:right motor sense; CDT:clock drawing test; DST:digit span test; CBT: corsi block-tapping test; HbO: oxyhemoglobin; Hb:deoxyhemoglobinsense cortex (MS) of participants in different groups.Results: Short-term memory and visuo-spatial abilities were assessed using clock drawing test (CDT), digit span test (DST) and Corsi Block-tapping (CBT) tests. and Mini-Mental State Examination (MMSE) scores were positively correlated with CDT and DST scores, but not with CBT scores. Within each group, the brain FC between left motor sense cortex (LMS) and right motor sense cortex (RMS) was the highest, and that between MSs (LMS and RMS) and PFC was the lowest. Compared with Healthy control (HC) and Stroke (STR) groups FC between MSs significantly decreased, and the difference was decreased in PSCI group. The PSCI group showed significantly lower FC between prefrontal lobes. FC levels were closely related to cognitive performance (MMSE scores).Conclusions: Decreased FC level may be a marker of impaired cognitive function in PSCI. The fNIRS-based FC network provides a non-invasive method to recognize PSCI. FC changes may help to further understand the neural mechanisms of PSCI. (the registration number:MR-43-22-003125.)
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
江璃完成签到,获得积分10
刚刚
TT发布了新的文献求助10
刚刚
美梦成真完成签到,获得积分10
1秒前
Gakay完成签到,获得积分10
1秒前
量子星尘发布了新的文献求助10
2秒前
szj完成签到,获得积分0
3秒前
旦皋完成签到,获得积分10
3秒前
赘婿应助花壳在逃野猪采纳,获得10
4秒前
卷卷完成签到,获得积分10
6秒前
JSY完成签到 ,获得积分20
6秒前
xyh完成签到,获得积分10
7秒前
小曾应助Florencia采纳,获得10
8秒前
神外王001完成签到 ,获得积分10
8秒前
13秒前
你是谁完成签到,获得积分10
14秒前
majf完成签到,获得积分10
15秒前
linhanwenzhou完成签到,获得积分10
15秒前
JSY关注了科研通微信公众号
15秒前
853225598完成签到,获得积分10
15秒前
798完成签到,获得积分10
16秒前
善学以致用应助董怼怼采纳,获得10
16秒前
妍儿完成签到,获得积分20
17秒前
隐形曼青应助高大的水壶采纳,获得10
17秒前
马哥二弟无敌完成签到 ,获得积分10
18秒前
19秒前
Florencia完成签到,获得积分10
19秒前
务实颜完成签到 ,获得积分10
19秒前
19秒前
amberzyc应助小远采纳,获得10
20秒前
20秒前
21秒前
21秒前
22秒前
22秒前
Rondab应助小猪采纳,获得30
22秒前
DLDL完成签到,获得积分10
22秒前
23秒前
沧海云完成签到 ,获得积分10
23秒前
发嗲的迎天完成签到 ,获得积分10
24秒前
hahaha发布了新的文献求助10
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038368
求助须知:如何正确求助?哪些是违规求助? 3576068
关于积分的说明 11374313
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029