PI3K/AKT/mTOR通路
蛋白激酶B
mTORC2型
信号转导
癌症研究
RPTOR公司
癌症
磷脂酰肌醇
从长凳到床边
mTORC1型
生物
细胞生物学
生物信息学
医学
遗传学
医学物理学
作者
Camillo Porta,Chiara Paglino,Alessandra Mosca
标识
DOI:10.3389/fonc.2014.00064
摘要
The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of Rapamycin (mTOR) signaling pathways are two pathways crucial to many aspects of cell growth and survival, in physiological as well as in pathological conditions (e.g. cancer). Indeed, they are so interconnected that, in a certain sense, they could be regarded as a single, unique pathway. In this paper, after a general overview of the biological significance and the main components of these pathways, we address the present status of the development of specific PI3K, Akt and mTOR inhibitors, from already registered medicines to novel compounds that are just leaving the laboratory bench.
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