肌萎缩侧索硬化
神经科学
小胶质细胞
中枢神经系统
神经系统
神经胶质
生物
疾病
医学
病理
免疫学
炎症
作者
Virenkumar A. Pandya,Rickie Patani
出处
期刊:International Review of Neurobiology
日期:2024-01-01
卷期号:: 381-450
标识
DOI:10.1016/bs.irn.2024.04.005
摘要
Amyotrophic lateral sclerosis (ALS) has traditionally been considered a neuron-centric disease. This view is now outdated, with increasing recognition of cell autonomous and non-cell autonomous contributions of central and peripheral nervous system glia to ALS pathomechanisms. With glial research rapidly accelerating, we comprehensively interrogate the roles of astrocytes, microglia, oligodendrocytes, ependymal cells, Schwann cells and satellite glia in nervous system physiology and ALS-associated pathology. Moreover, we highlight the inter-glial, glial-neuronal and inter-system polylogue which constitutes the healthy nervous system and destabilises in disease. We also propose classification based on function for complex glial reactive phenotypes and discuss the pre-requisite for integrative modelling to advance translation. Given the paucity of life-enhancing therapies currently available for ALS patients, we discuss the promising potential of harnessing glia in driving ALS therapeutic discovery.
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