间质细胞
岩石1
间充质干细胞
癌症研究
干细胞
胚胎干细胞
转化生长因子
增生
细胞生物学
化学
医学
内分泌学
生物
激酶
蛋白激酶A
生物化学
基因
作者
Youyou Li,Jiaren Li,Liang Zhou,Zhenxing Wang,Jin Liu,Jia Cao,Hui Xie,Long Wang
标识
DOI:10.1186/s12964-024-01644-4
摘要
Abstract Benign prostatic hyperplasia (BPH) is a multifactorial disease in which abnormal growth factor activation and embryonic reawakening are considered important factors. Here we demonstrated that the aberrant activation of transforming growth factor β (TGF-β)/Rho kinase 1 (ROCK1) increased the stemness of BPH tissue by recruiting mesenchymal stem cells (MSCs), indicating the important role of embryonic reawakening in BPH. When TGF-β/ROCK1 is abnormally activated, MSCs are recruited and differentiate into fibroblasts/myofibroblasts, leading to prostate stromal hyperplasia. Further research showed that inhibition of ROCK1 activation suppressed MSC migration and their potential for stromal differentiation. Collectively, our findings suggest that abnormal activation of TGF-β/ROCK1 regulates stem cell lineage specificity, and the small molecule inhibitor GSK269962A could target ROCK1 and may be a potential treatment for BPH. Graphical Abstract
科研通智能强力驱动
Strongly Powered by AbleSci AI