视网膜色素上皮
视网膜变性
黄斑变性
视网膜
视网膜
生物
氧化应激
细胞生物学
基因剔除小鼠
炎症
免疫学
医学
内分泌学
受体
遗传学
神经科学
眼科
生物化学
作者
Jian Liu,David A. Copland,Alison J. Clare,Mathias Gorski,Burt T. Richards,Louis Scott,Sofia Theodoropoulou,Ursula Greferath,Katherine Cox,Gongyu Shi,Oliver H. Bell,K. Ou,J. Powell,Jiahui Wu,Luis Robles,Y. Li,Lindsay B. Nicholson,Peter Coffey,Erica L. Fletcher,Robyn H. Guymer
标识
DOI：10.1126/scitranslmed.adi4125
摘要
Chronic inflammation is a constitutive component of many age-related diseases, including age-related macular degeneration (AMD). Here, we identified interleukin-1 receptor-associated kinase M (IRAK-M) as a key immunoregulator in retinal pigment epithelium (RPE) that declines during the aging process. Rare genetic variants of
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