Active methods of drug loading into liposomes: recent strategies for stable drug entrapment and increasedin vivoactivity

Introduction: The use of liposomes increases the therapeutic index of many drugs, and also offers drug targeting and controlled release. The commercial impact of liposomes is strengthened by the invention of several active drug encapsulation methods, allowing the encapsulation of several weak base or weak acid drugs with very high drug-to-lipid ratios.