焦测序
重叠感染
生物
病毒学
人类免疫缺陷病毒(HIV)
疾病
遗传学
医学
基因
内科学
病毒
作者
Gabriel A. Wagner,Mary E. Pacold,Edgar Vigil,Gemma Caballero,Sheldon Morris,Sergei L. Kosakovsky Pond,Susan J. Little,Douglas D. Richman,Sara Gianella,Davey M. Smith
标识
DOI:10.1093/infdis/jit168
摘要
HIV-1 dual infection (DI) and CXCR4 (X4) coreceptor usage are associated with accelerated disease progression but frequency and dynamics of coreceptor usage during DI is unknown. Ultradeep sequencing was used to interrogate for DI and infer coreceptor usage in longitudinal blood samples of 102 subjects. At baseline, X4 usage was high (23 subjects harbored X4 variants) and was not associated with infection duration or DI. Coreceptor usage changed over time in 12 of 47 participants, and X4 usage emerged in 4 of 41 monoinfections vs 2 of 5 superinfections (P = .12), suggesting a weak statistical trend toward occurrence of superinfection and acquiring X4 usage.
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