平衡
免疫系统
生物
细胞生物学
粘膜免疫学
允许的
白细胞介素22
胃肠道
功能(生物学)
寄主(生物学)
免疫
免疫学
微生物学
先天免疫系统
细胞因子
白细胞介素
生态学
生物化学
遗传学
作者
Lance W. Peterson,David Artis
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2014-02-25
卷期号:14 (3): 141-153
被引量:2405
摘要
The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host-microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host-commensal microbial relationships and immune cell homeostasis in the intestine.
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