次生代谢
生物
杂色曲霉素
次生代谢物
巢状曲霉
真菌毒素
丝状真菌
真菌
生物合成
基因
生物化学
生物技术
植物
突变体
作者
Jae-Hyuk Yu,Nancy P. Keller
出处
期刊:Annual Review of Phytopathology
[Annual Reviews]
日期:2005-09-01
卷期号:43 (1): 437-458
被引量:465
标识
DOI:10.1146/annurev.phyto.43.040204.140214
摘要
Fungal secondary metabolites are of intense interest to humankind due to their pharmaceutical (antibiotics) and/or toxic (mycotoxins) properties. In the past decade, tremendous progress has been made in understanding the genes that are associated with production of various fungal secondary metabolites. Moreover, the regulatory mechanisms controlling biosynthesis of diverse groups of secondary metabolites have been unveiled. In this review, we present the current understanding of the genetic regulation of secondary metabolism from clustering of biosynthetic genes to global regulators balancing growth, sporulation, and secondary metabolite production in selected fungi with emphasis on regulation of metabolites of agricultural concern. Particularly, the roles of G protein signaling components and developmental regulators in the mycotoxin sterigmatocystin biosynthesis in the model fungus Aspergillus nidulans are discussed in depth.
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