核磷蛋白
核出口信号
生物
核运输
核孔蛋白
核蛋白
跑
序列(生物学)
细胞核
计算生物学
生物信息学
遗传学
核心
生物化学
细胞生物学
基因
转录因子
作者
Darui Xu,Nick V. Grishin,Yuh Min Chook
标识
DOI:10.1091/mbc.e12-01-0045
摘要
The leucine-rich nuclear export signal (NES) is the only known class of targeting signal that directs macromolecules out of the cell nucleus. NESs are short stretches of 8–15 amino acids with regularly spaced hydrophobic residues that bind the export karyopherin CRM1. NES-containing proteins are involved in numerous cellular and disease processes. We compiled a database named NESdb that contains 221 NES-containing CRM1 cargoes that were manually curated from the published literature. Each NESdb entry is annotated with information about sequence and structure of both the NES and the cargo protein, as well as information about experimental evidence of NES-mapping and CRM1-mediated nuclear export. NESdb will be updated regularly and will serve as an important resource for nuclear export signals. NESdb is freely available to nonprofit organizations at http://prodata.swmed.edu/LRNes .
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