Controlled PEGylation of Monodisperse Fe3O4 Nanoparticles for Reduced Non‐Specific Uptake by Macrophage Cells

Advanced MaterialsVolume 19, Issue 20 p. 3163-3166 Communication Controlled PEGylation of Monodisperse Fe3O4 Nanoparticles for Reduced Non-Specific Uptake by Macrophage Cells† J. Xie, J. Xie Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this authorC. Xu, C. Xu Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this authorN. Kohler, N. Kohler Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this authorY. Hou, Y. Hou Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this authorS. Sun, S. Sun [email protected] Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this author J. Xie, J. Xie Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this authorC. Xu, C. Xu Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this authorN. Kohler, N. Kohler Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this authorY. Hou, Y. Hou Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this authorS. Sun, S. Sun [email protected] Department of Chemistry, Brown University, Providence, RI 02912 (USA)Search for more papers by this author First published: 17 October 2007 https://doi.org/10.1002/adma.200701975Citations: 576 † The work was supported by DARPA/ONR under grant Nos. N00014-01-1-0885, NERCE 14898830458, NSF/DMR 0606264, the Salomon award from Brown University, and the Frontier Research award from the Department of Chemistry, Brown University. Supporting Information is available online from Wiley InterScience or from the authors. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract A dopamine-PEG based ligand is synthesized and used to stabilize monodisperse 9 nm Fe3O4 nanoparticles in physiological conditions and against non-specific uptake by macrophage cells. Such stable nanoparticles can be used to enhance the efficiency in target-specific drug delivery and to increase the signal-to-noise ratio in magnetic resonance imaging (MRI). Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c1975_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCES 1 Q. A. Pankhurst, J. Connolly, S. K. Jones, J. Dobson, J. Phys. D Appl. Phys. 2003, 36, R167. 2 S. Mornet, S. Vasseur, F. Grasset, E. Duguet, J. Mater. Chem. 2004, 14, 2161. 3 C. C. Berry, A. S. G. Curtis, J. Phys. D Appl. Phys. 2003, 36, R198. 4 S. M. Moghimi, A. C. Hunter, J. C. Murray, Pharm. Rev. 2001, 53, 283. 5 L. M. Lacava, Z. G. Lacava, M. F. Da Silva, O. Silva, S. B. Chaves, R. B. Azevedo, F. Pelegrini, C. Gansau, N. Buske, D. Sabolovic, P. C. Morais, Biophys. J. 2001, 80, 2483. 6 E. Strable, J. W. M. Bulte, B. Moskowitz, K. Vivekanandan, M. Allen, T. 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