生物相容性
纳米复合材料
核化学
材料科学
傅里叶变换红外光谱
铈
抗菌活性
纳米颗粒
热稳定性
纳米技术
化学工程
化学
冶金
有机化学
工程类
细菌
生物
遗传学
作者
Priyadarshini Baskaran,Anjaneyulu Udduttula,U. Vijayalakshmi
出处
期刊:Iet Nanobiotechnology
[Institution of Electrical Engineers]
日期:2017-09-15
卷期号:12 (2): 138-146
被引量:25
标识
DOI:10.1049/iet-nbt.2017.0029
摘要
Hydroxyapatite (HAP: Ca10 (PO4)6 (OH)2) is extensively used in biomedical field because of its biocompatibility, osteoconductivity and non-toxicity properties. However, HAP exhibits poor mechanical strength and bacterial restriction behavior. To overcome these drawbacks, various metal ions such as Ag+, Zn2+, Cu2+, Ti4+ and Ce4+/3+ are incorporated in HAP matrix to increase the mechanical and biological properties. Among these, Cerium (Ce) is selected as antibacterial agent due to its high thermal stability and its applications in dental fillings, bone healing and catheters. Fe3 O4 nanoparticles were used in hyperthermia treatment, magnetic fluid recordings and catalysis. In this present study, we have synthesized nanocomposites consisting of 1.25% Ce doped HAP with various concentrations of Fe3 O4 NPs as 90:10 (C-1), 70:30 (C-2) and 50:50 wt% (C-3) using ball milling technique. The obtained Ce@HAP-Fe3 O4 nanocomposites were characterized by ATR-FTIR, XRD, VSM, SEM-EDAX and TEM analysis. Further, the fabricated Ce@HAP-Fe3 O4 nanocomposites were tested for its antibacterial activity towards Staphylococcus aureus (S. aureus) and Escherichia coli (E.coli), where C-3 composites exhibit the excellent pathogen inhibition towards E.coli. In addition, the cytotoxicity evaluation on C-3 nanocomposites by in vitro biocompatibility study using MG-63 cells shows the prominent viable cell enhancement up to 400µg/mL concentrations.
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