Iron-based degradable implants present a significant advantage over magnesium and zinc-based devices, since they possess a better combination of strength and ductility. However, their degradation inside the body proceeds too slowly. In this article, the different applications and classes of iron-based implants are examined. Moreover, testing methods for assessing their biological performances are discussed. This will allow to understand how new materials can be designed, in order that they can hit the market while possessing superior properties with respect to currently commercialized implants.