胶质瘤
RNA序列
核糖核酸
生物
细胞
计算生物学
细胞生物学
基因表达
遗传学
基因
转录组
作者
Mariella G. Filbin,Itay Tirosh,Volker Hovestadt,McKenzie Shaw,Leah E. Escalante,Nathan D. Mathewson,Cyril Neftel,Nelli Frank,Kristine Pelton,Christine Hebert,Christine Haberler,Keren Yizhak,Johannes Gojo,Kristóf Égervári,Christopher Mount,Peter van Galen,Dennis M. Bonal,Quang‐Dé Nguyen,Alexander Beck,Claire Sinai
出处
期刊：Science
[American Association for the Advancement of Science]
日期：2018-04-20
卷期号：360 (6386): 331-335
被引量：728
标识
DOI：10.1126/science.aao4750
摘要
signaling. Our study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.
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