对映选择合成
氰化物
组合化学
化学
有机化学
催化作用
作者
Tobias Betke,Philipp Rommelmann,Keiko Oike,Yasuhisa Asano,Harald Gröger
标识
DOI:10.1002/anie.201702952
摘要
Abstract A cyanide‐free platform technology for the synthesis of chiral nitriles by biocatalytic enantioselective dehydration of a wide range of aldoximes is reported. The nitriles were obtained with high enantiomeric excess of >90 % ee (and up to 99 % ee ) in many cases, and a “privileged substrate structure” with respect to high enantioselectivity was identified. Furthermore, a surprising phenomenon was observed for the enantiospecificity that is usually not observed in enzyme catalysis. Depending on whether the E or Z isomer of the racemic aldoxime substrate was employed, one or the other enantiomer of the corresponding nitrile was formed preferentially with the same enzyme.
科研通智能强力驱动
Strongly Powered by AbleSci AI