细胞生物学
衰老
细胞衰老
DNA损伤
生物
内生
细胞老化
细胞周期检查点
老化
程序性细胞死亡
癌细胞
细胞应激反应
细胞周期
端粒
细胞
战斗或逃跑反应
癌症
细胞凋亡
表型
遗传学
DNA
生物化学
基因
作者
Judith Campisi,Fabrizio d’Adda di Fagagna
摘要
Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.
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