Altered fecal microbiota composition in patients with major depressive disorder

厚壁菌 重性抑郁障碍 拟杆菌 粪便 蛋白质细菌 肠道菌群 微生物群 焦测序 内科学 双歧杆菌 医学 生物 乳酸菌 生态学 免疫学 生物信息学 细菌 生物化学 遗传学 基因 扁桃形结构 16S核糖体RNA
作者
Hai‐yin Jiang,Zongxin Ling,Yonghua Zhang,Hongjin Mao,Zhanping Ma,Yi Yin,Weihong Wang,Wenxin Tang,Zhonglin Tan,Jianfei Shi,Lanjuan Li,Bing Ruan
出处
期刊:Brain Behavior and Immunity [Elsevier]
卷期号:48: 186-194 被引量:1481
标识
DOI:10.1016/j.bbi.2015.03.016
摘要

Studies using animal models have shown that depression affects the stability of the microbiota, but the actual structure and composition in patients with major depressive disorder (MDD) are not well understood. Here, we analyzed fecal samples from 46 patients with depression (29 active-MDD and 17 responded-MDD) and 30 healthy controls (HCs). High-throughput pyrosequencing showed that, according to the Shannon index, increased fecal bacterial α-diversity was found in the active-MDD (A-MDD) vs. the HC group but not in the responded-MDD (R-MDD) vs. the HC group. Bacteroidetes, Proteobacteria, and Actinobacteria strongly increased in level, whereas that of Firmicutes was significantly reduced in the A-MDD and R-MDD groups compared with the HC group. Despite profound interindividual variability, levels of several predominant genera were significantly different between the MDD and HC groups. Most notably, the MDD groups had increased levels of Enterobacteriaceae and Alistipes but reduced levels of Faecalibacterium. A negative correlation was observed between Faecalibacterium and the severity of depressive symptoms. These findings enable a better understanding of changes in the fecal microbiota composition in such patients, showing either a predominance of some potentially harmful bacterial groups or a reduction in beneficial bacterial genera. Further studies are warranted to elucidate the temporal and causal relationships between gut microbiota and depression and to evaluate the suitability of the microbiome as a biomarker.
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