化学
等温滴定量热法
分子印迹
分子印迹聚合物
纳米材料
生物传感器
人工酶
辣根过氧化物酶
印记(心理学)
酶
基质(水族馆)
聚合物
分子识别
生物催化
组合化学
纳米技术
催化作用
生物化学
有机化学
选择性
分子
离子液体
地质学
材料科学
海洋学
基因
作者
Zijie Zhang,Xiaohan Zhang,Biwu Liu,Juewen Liu
摘要
Enzyme-mimicking nanomaterials (nanozymes) are more cost-effective and robust than protein enzymes, but they lack specificity. Herein, molecularly imprinted polymers were grown on Fe3O4 nanozymes with peroxidase-like activity to create substrate binding pockets. Electron microscopy confirmed a shell of nanogel. By imprinting with an adsorbed substrate, moderate specificity was achieved with neutral monomers. Further introducing charged monomers led to nearly 100-fold specificity for the imprinted substrate over the nonimprinted compared to that of bare Fe3O4. Selective substrate binding was further confirmed by isothermal titration calorimetry. The same method was also successfully applied for imprinting on gold nanoparticles (peroxidase mimics) and nanoceria (oxidase mimics). Molecular imprinting furthers the functional enzyme mimicking aspect of nanozymes, and such hybrid materials will find applications in biosensor development, separation, environmental remediation, and drug delivery.
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