临床试验
医学
再生医学
标准化
重症监护医学
临床研究设计
伤口护理
再生(生物学)
替代医学
病理
干细胞
计算机科学
遗传学
生物
细胞生物学
操作系统
作者
Mohammad Ali Nilforoushzadeh,Mahsa Mollapour Sisakht,Alexander M. Seifalian,Mohammad Amir Amirkhani,Hamid Reza Banafshe,Javad Verdi,Farzaneh Sharifzad,Ehsan Taghiabadi
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2017-11-03
卷期号:12 (8)
被引量:15
标识
DOI:10.2174/1574888x12666170929123842
摘要
Background: During the last two decades, a number of studies have been carried out on the application of regenerative medicine in the field of dermatology. Objective: The aim of this research was to critically review the application of regenerative medicine in the field of dermatology. The next aim was to look in depth to see whether regenerative medicine strategies have a place in the future of wound healing in a clinical setting. More specifically, to see if these strategies would apply for burns and non-healing diabetic wounds. Results: Billions of dollars have been spent worldwide on research in wound treatment and skin regeneration. Although a high number of clinical trials show promising results, there is still no commercially available treatment for use. In addition, the outcome data from the clinical trials, taking place throughout the world, are not published in a standardized manner. Standardization within clinical trials is required for: protocols, outcome, endpoint values, and length of follow-up. The lack of standardization makes it much more difficult to compare the data collected and the different types of treatment. Conclusion: Despite several promising results from research and early phase clinical studies, the treatment for wounds as well as skin regeneration is still considered as an unmet clinical need. However, in the past three years, more promising research has been approaching clinical trials; this could be the solution that clinicians have been waiting for. This is a multibillion dollar industry for which there should be enough incentive for researchers and industry to seek the solution. Keywords: Regenerative medicine, cell therapy, wound, dermatology, skin, skin stem cell.
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