D-二聚体
医学
纤溶
静脉血栓栓塞
纤维蛋白
凝结
背景(考古学)
弥漫性血管内凝血
重症监护医学
内科学
血栓形成
免疫学
生物
古生物学
作者
Jeffrey I. Weitz,James C. Fredenburgh,John W. Eikelboom
标识
DOI:10.1016/j.jacc.2017.09.024
摘要
D-dimer is a soluble fibrin degradation product that results from ordered breakdown of thrombi by the fibrinolytic system. Numerous studies have shown that D-dimer serves as a valuable marker of activation of coagulation and fibrinolysis. Consequently, D-dimer has been extensively investigated for the diagnosis of venous thromboembolism (VTE) and is used routinely for this indication. In addition, D-dimer has been evaluated for determining the optimal duration of anticoagulation in VTE patients, for diagnosing and monitoring disseminated intravascular coagulation, and as an aid in the identification of medical patients at high risk for VTE. Thus, quantification of D-dimer levels serves an important role in guiding therapy. This review: 1) describes how D-dimer is generated; 2) reviews the assays used for its detection; and 3) discusses the role of D-dimer determination in these various conditions.
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