血管生成
血管内皮生长因子
受体酪氨酸激酶
癌症研究
受体
调节器
生物
激酶插入结构域受体
血管内皮生长因子A
信号转导
血管内皮生长因子受体
酪氨酸激酶
细胞生物学
黄斑变性
医学
遗传学
眼科
基因
作者
Napoleone Ferrara,Hans‐Peter Gerber,Jennifer LeCouter
出处
期刊:Nature Medicine
[Springer Nature]
日期:2003-05-30
卷期号:9 (6): 669-676
被引量:9184
摘要
Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2, which differ considerably in signaling properties. Non-signaling co-receptors also modulate VEGF RTK signaling. Currently, several VEGF inhibitors are undergoing clinical testing in several malignancies. VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration.
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