mTORC1型
PI3K/AKT/mTOR通路
mTORC2型
癌症研究
雷帕霉素的作用靶点
mTOR抑制剂的发现与发展
西罗莫司
医学
RPTOR公司
生物
细胞生长
信号转导
靶向治疗
癌症
临床试验
计算生物学
肿瘤科
依维莫司
生物信息学
梅德林
精密医学
细胞生物学
遗传学
内科学
作者
Seth A. Wander,Bryan T. Hennessy,Joyce M. Slingerland
摘要
Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2. The mTOR pathway is often aberrantly activated in cancers. While hypoxia, nutrient deprivation, and DNA damage restrain mTORC1 activity, multiple genetic events constitutively activate mTOR in cancers. Here we provide a brief overview of the signaling pathways up- and downstream of mTORC1 and -2, and discuss the insights into therapeutic anticancer targets - both those that have been tried in the clinic with limited success and those currently under clinical development - that knowledge of these pathways gives us.
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