斯达
STAT1
STAT蛋白
状态4
受体
转录因子
细胞生物学
化学
JAK-STAT信号通路
分子生物学
生物
信号转导
生物化学
车站3
基因
酪氨酸激酶
作者
Pengguang Wu,Mike Brasseur,Ulrike Schindler
标识
DOI:10.1006/abio.1997.2158
摘要
STAT (signal transducers and activators of transcription) is a class of transcription factors that are activated upon cytokine or growth factor binding to cell surface receptors. Activated STAT proteins dimerize, translocate into the nucleus, and activate transcription, leading to various immune responses. The inhibition of STAT binding to cell receptors might provide a means to modulate these immune responses. We developed a high-throughput biochemical assay to measure the interaction between an interferon-γ receptor-derived phosphotyrosine-containing peptide and STAT1, using fluorescence polarization as the detection method. This assay can be used to screen for small molecules capable of disrupting receptor–STAT interactions.
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