医学
萎缩
高强度
额叶
心脏病学
白质疏松症
神经心理学
白质
冲程(发动机)
认知
基于体素的形态计量学
内科学
听力学
磁共振成像
放射科
精神科
机械工程
工程类
作者
Marta Grau-Olivares,Adrià Arboix,Carme Junqué,Eider M. Arenaza‐Urquijo,Mariana Rovira,David Bartrés‐Faz
出处
期刊:Cerebrovascular Diseases
[S. Karger AG]
日期:2010-01-01
卷期号:30 (2): 157-166
被引量:76
摘要
We investigated the progression of cognitive and cerebral changes in 30 patients with a first-ever lacunar infarct (LI): 15 with vascular mild cognitive impairment (MCI-V) and 15 without cognitive impairment. All cases were followed up 18 +/- 6 months after the stroke and underwent neurological, neuropsychological and MRI assessments at baseline and longitudinally.Differences in the changes in cognitive function over time were observed between the 2 groups, with the MCI-V patients showing slight memory improvements and frontal-lobe-related test impairments from baseline to follow-up evaluations. At baseline, the 2 groups presented similar white matter hyperintensity (WMH) ratings and whole brain gray matter (GM) volumes, and at the follow-up evaluations, both groups had increased WMH lesions and decreased GM volumes; no statistical differences between groups were found. In contrast, a voxel-based morphometry analysis revealed that only MCI-V patients presented clear regional GM volume losses between the first and the second evaluations in cortical (frontal and temporal) and subcortical (pons, cerebellum and caudate) regions.Frontal lobe dysfunction and regional cortical and subcortical GM atrophy best differentiate the clinical course of LI patients with and without cognitive impairment.
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