化学
产肠毒素大肠杆菌
肠毒素
热稳定性肠毒素
大肠杆菌
毒性
微生物学
生物化学
有机化学
生物
基因
作者
Shinji Yamasaki,Yuji Hidaka,Hideaki Ito,Yoshifumi Takeda,Yasutsugu Shimonishi
摘要
Abstract The heat-stable enterotoxin (STh) of enterotoxigenic Escherichia coli consists of 19 amino acid residues and is linked intramolecularly by three disulfide bonds between Cys6 and Cys11, Cys7 and Cys15, and Cys10 and Cys18 (Y. Shimonishi et al., FEBS Lett., 215, 165 (1987)). The syntheses and biological assays of various analogs of STh with one or two of the three disulfide bonds showed that a disulfide bond between Cys7 and Cys15 and another between Cys6 and Cys11 or Cys10 and Cys18 are necessary for construction and stabilization of the spatial structure of STh to express its toxicity.
科研通智能强力驱动
Strongly Powered by AbleSci AI