泊洛沙姆
海绵
材料科学
生物医学工程
复合材料
医学
共聚物
聚合物
植物
生物
作者
João Paulo Mardegan Issa,Cássio do Nascimento,Mamie Mizusaki Iyomasa,Selma Siéssere,Simone Cecílio Hallak Regalo,Helton Luíz Aparecido Defino,Walter Sebald
出处
期刊:Micron
[Elsevier]
日期:2008-01-01
卷期号:39 (1): 17-24
被引量:19
标识
DOI:10.1016/j.micron.2007.08.008
摘要
The bone morphogenetic protein type 2, is an osteoinduction protein, but new carriers to improve its actions are being studied in recent researches. The objective of this study was to evaluate the poloxamer gel as potential carrier of the rhBMP-2 during the bone healing process and verify if the collagen sponge can improve this process. Fifty-six male Wistar rats were used, which were divided into two groups, considering two periods of time. Thus, each one of these groups was divided in four groups with seven animals each, according to the treatment and the defect filled by 4 microg rhBMP-2 in aqueous solution, 4 microg rhBMP-2 in aqueous solution+collagen sponge, 4 microg rhBMP-2 combined with poloxamer gel, and 4 microg rhBMP-2 combined with poloxamer gel+collagen sponge. After 2 and 4 weeks, respectively, animals were perfused and the hemi-mandibles removed for histological analysis. Statistical analysis of the data showed significant difference between all analyzed groups (p<0.01), and between the periods of time (p=0.0118). There was no interaction between the applied treatment and considered periods of time (p=0.642). Results showed that the rhBMP-2 used in this study was able to induce bone regeneration and had its action optimized when combined to the used carriers, being the bone repair time-dependent.
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