可选择标记
生物
计算生物学
逆转录病毒
基因
选择(遗传算法)
遗传学
质粒
计算机科学
人工智能
出处
期刊:Human Gene Therapy
[Mary Ann Liebert]
日期:1991-10-01
卷期号:2 (3): 195-201
被引量:19
标识
DOI:10.1089/hum.1991.2.3-195
摘要
As more complicated gene expression studies are necessary, the need for multiple positive selection schemes becomes critical. Numerous selectable markers have been described over the last 25 years. A hallmark of the most generally useful markers is easy selection in a wide number of cell types. This paper briefly reviews the spectrum of available selectable markers and describes some of the applications that have been found for these genes, particularly with respect to retrovirus-mediated gene transfer. This review summarizes the positive selectable markers available to mammalian cell biologists and molecular biologists. Some of the applications found for these markers, particularly with respect to retroviral vectors, are discussed.
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