人工细胞
纳米技术
细胞包封
封装(网络)
细胞
材料科学
细胞代谢
细胞代谢
内孢子
再生医学
生物物理学
孢子
化学
生物
计算机科学
新陈代谢
生物化学
微生物学
膜
计算机网络
作者
Sung Ho Yang,Daewha Hong,Juno Lee,Eun Hyea Ko,Insung S. Choi
出处
期刊:Small
[Wiley]
日期:2012-11-02
卷期号:9 (2): 178-186
被引量:113
标识
DOI:10.1002/smll.201202174
摘要
Abstract Cells are encapsulated individually within thin and tough shells in a cytocompatible way, by mimicking the structure of bacterial endospores that survive under hostile conditions. The 3D ‘cell‐in‐shell’ structures—coined as ‘artificial spores'—enable modulation and control over cellular metabolism, such as control of cell division, resistance to external stresses, and surface‐functionalizability, providing a useful platform for applications, including cell‐based sensors, cell therapy, regenerative medicine, as well as for fundamental studies on cellular metabolism at the single‐cell level and cell‐to‐cell communications. This Concept focuses on chemical approaches to single‐cell encapsulation with artificial shells for creating artificial spores, including cross‐linked layer‐by‐layer assembly, bioinspired mineralization, and mussel‐inspired polymerization. The current status and future prospects of this emerging field are also discussed.
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