作者
Aditya Bardia,Sara A. Hurvitz,Sara M. Tolaney,Delphine Loirat,Kevin Punie,Mafalda Oliveira,Adam Brufsky,Sagar Sardesai,Kevin Kalinsky,Amelia Zelnak,Robert Weaver,Tiffany A. Traina,Florence Dalenc,Philippe Aftimos,Filipa Lynce,Sami Diab,Javier Cortés,Joyce O’Shaughnessy,Véronique Dièras,Cristiano Ferrario,Peter Schmid,Lisa A. Carey,Luca Gianni,Martine Piccart,Sibylle Loibl,David M. Goldenberg,Yi Qu,Martin Olivo,Loretta M. Itri,Hope S. Rugo
摘要
Patients with metastatic triple-negative breast cancer have a poor prognosis. Sacituzumab govitecan is an antibody-drug conjugate composed of an antibody targeting the human trophoblast cell-surface antigen 2 (Trop-2), which is expressed in the majority of breast cancers, coupled to SN-38 (topoisomerase I inhibitor) through a proprietary hydrolyzable linker.