丝素
材料科学
生物相容性
苯硼酸
胰岛素释放
制作
生物医学工程
纳米技术
自愈水凝胶
药物输送
水溶液
生物相容性材料
丝绸
化学
高分子化学
复合材料
有机化学
医学
1型糖尿病
糖尿病
内分泌学
替代医学
病理
冶金
催化作用
作者
Siyuan Chen,Hiroko Matsumoto,Yuki Moro‐oka,Miyako Tanaka,Yuji Miyahara,Takayoshi Suganami,Akira Matsumoto
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2019-07-02
卷期号:5 (11): 5781-5789
被引量:96
标识
DOI:10.1021/acsbiomaterials.9b00532
摘要
Microneedle (MN) technology, which can transdermally deliver insulin in a noninvasive manner, offers a promising way to replace subcutaneous self-injection for diabetes management. Hydrogel is an attractive candidate for MN fabrication because of its biocompatibility, controllable degradability, and possibility to achieve sustained as well as stimuli-responsive drug delivery. Herein, we report a smart MN composed of a semi-interpenetrating network (semi-IPN) hydrogel prepared by biocompatible silk fibroin (SF) and phenylboronic acid/acrylamide for glucose-responsive insulin delivery. Six fabrication methods were investigated to maintain the glucose sensitivity of the hydrogel while avoiding deformation during fabrication. The optimized method was to fabricate smart MNs using a two-layer strategy, with a needle region formed by the SF combined semi-IPN hydrogel and the base layer fabricated by SF. The hybrid MN autonomously released insulin well-correspondent to the glucose change pattern via the regulation of the skin layer formed on the surface. Furthermore, this hybrid MN retained its original needle shape after 1 week in aqueous system, thus eliminating the safety concerns associated with dissolving MNs and suggesting the possibility for sustained delivery. This nondegradable smart MN is promising to provide on-demand insulin in a long-acting, painless, and convenient way.
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