肌萎缩
医学
骨质疏松症
流行病学
重症监护医学
人口
病因学
老年学
内科学
物理疗法
环境卫生
作者
Michael Clynes,Celia L. Gregson,Olivier Bruyère,Cyrus Cooper,Elaine Dennison
出处
期刊:Rheumatology
[Oxford University Press]
日期:2020-10-30
卷期号:60 (2): 529-537
被引量:124
标识
DOI:10.1093/rheumatology/keaa755
摘要
Abstract The coexistence of osteoporosis and sarcopenia has been recently considered in some groups as a syndrome termed ‘osteosarcopenia’. Osteoporosis describes low bone mass and deterioration of the micro-architecture of the bone, whereas sarcopenia is the loss of muscle mass, strength and function. With an ageing population the prevalence of both conditions is likely to increase substantially over the coming decades and is associated with significant personal and societal burden. The sequelae for an individual suffering from both conditions together include a greater risk of falls, fractures, institutionalization and mortality. The aetiology of ‘osteosarcopenia’ is multifactorial with several factors linking muscle and bone function, including genetics, age, inflammation and obesity. Several biochemical pathways have been identified that are facilitating the development of several promising therapeutic agents, which target both muscle and bone. In the current review we outline the epidemiology, pathogenesis and clinical consequences of ‘osteosarcopenia’ and explore current and potential future management strategies.
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