材料科学
安定
自愈水凝胶
泊洛沙姆
药物输送
渗透
化学工程
色谱法
复合材料
化学
纳米技术
药理学
聚合物
高分子化学
共聚物
医学
生物化学
工程类
膜
作者
Seyed Hassan Montazam,Sara Salatin,Mitra Alami-Milani,Amir Said Alizadeh Naderi,Mitra Jelvehgari
出处
期刊:Therapeutic Delivery
[Newlands Press Ltd]
日期:2019-12-18
卷期号:11 (1): 813-830
被引量:6
标识
DOI:10.4155/tde-2019-0078
摘要
Aim: The aim of the present work was to develop an in situ thermosensitive rectal gel for diazepam by using Expert-design for improving three factors and a three-level process was formed by using a cold method. Methods & materials: Response surface design was utilized to investigate the effect of independent variables like sodium chloride (NaCl, X1), poloxamer 407 (F-127, X2) and diazepam (X3), on different dependent variables such as gelation temperature, mucoadhesive strength, drug content, along with permeation and stability. Results: The obtained results revealed that the addition of diazepam enhanced the gelation temperature of hydrogel while it decreased the gel strength and mucoadhesive force. Conclusion: It is suggested that in situ hydrogels may be suitable candidates for rectal delivery.
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